This sounds like something that should happen.
Resident Evil has quite a few things that would be neat in a rpg enviroment much like Mario RPG Legend of he Seven Stars.
Wesker could have constant appeances and it he would be like the Sephiroth or the Alex of the series.
Having a few protagonists at once, Chris, Jill, Leon and Clair in whom needs to be playable more often she's my favorite, just a fw examples, there are others who could playable too.
The monsters from the Resident Evil series could now be random encounters, which isn't hard to do.
Nice idea TFS Nappa, and good luck with your hack.